Game Week: Panthers Commence Conference Play vs. Louisville

PITTSBURGH – The Panthers commence conference play this weekend as they host Louisville at Acrisure Stadium. Pitt has won seven of their past 10 encounters with the Cardinals.

Louisville Game Week

PITT vs. LOUISVILLE

September 27, 2025 • Noon

Acrisure Stadium (68,400/Natural Grass) • Pittsburgh, Pa.

ESPN2 • 93.7 The Fan • Pitt Panthers Radio Network

PittsburghPanthers.com • @Pitt_FB

GAME STORYLINES

Louisville boasts the league's No. 2-ranked defense (244.7 ypg), while the Panthers have the ACC's third-best scoring offense (43.3 ppg).
Eli Holstein has completed 58 of 88 passes for 822 yards and nine touchdowns through the first three games of the season. He leads the league in passing efficiency (171.30) and ranks third in total offensive touchdowns (10). Additionally, the redshirt sophomore is first in the ACC in passing yards per completion (14.2) and third in passing scores (nine).
Raphael "Poppi" Williams Jr. has caught 12 passes for 245 yards and three touchdowns through the first three games of 2025. He ranks fourth in the ACC in receiving touchdowns, fourth in yards per catch (20.4) and sixth in receiving yards per game (81.7).
Rasheem Biles leads the entire conference in tackles per game (10.0) after recording 15 against West Virginia in Week 3.
Pitt offensive line coach Jeremy Darveau was a starting tackle for a pair of nationally ranked Louisville teams (2004-05) that featured some of the best offenses in school history.
Eight 2025 inductees will be honored during today's game as the newest members of the Pitt Athletics Hall of Fame, including former football players Aaron Donald (2010-13) and Bob Jury (1974-77).
During their last meeting in Pittsburgh, host Pitt defeated the previously undefeated no. 14 ranked Cardinals, 38-21, on Oct. 14, 2023.